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Butler Journal of Undergraduate Research

Faculty Sponsor

Dr. Brickman

Abstract

Moderate ethanol preconditioning, a result of prolonged moderate alcohol intake, serves as a protective process by staving off cognitive decline while providing neuronal protection through several mechanisms. These individual mechanisms are relatively well known, however a comprehensive and integrated conversation of ethanol’s protective tendencies is lacking from literature and the field of neuroscience. First, a review of the leading theories behind moderate ethanol preconditioning’s biological and cognitive benefits is presented, including overviews of neuroprotective, antioxidant, and neurotropic mechanisms responsible for neurological benefit. Secondly, an integrative model is presented, incorporating all research into a novel collaborative model. An additional discussion regarding the efficacy of ethanol treatments follow the comprehensive and integrated model.