Pharmacy, Health Sciences & Exercise Science
Event Title
Familial Precocious Puberty: Case Reports and Literature Review
Document Type
Oral Presentation
Location
Indianapolis, IN
Subject Area
Pharmacy, Health Sciences & Exercise Science
Start Date
11-4-2014 8:30 AM
End Date
11-4-2014 10:00 AM
Sponsor
Jeanne VanTyle (Butler University)
Description
Background: Precocious puberty is a relatively rare disease with little documented information on etiology or long-term complications.
Methods: Three cases of familial precocious puberty within a single family are reported. Two sisters inherited a gene malformation from their father who was untreated as a child. A literature review of "precocious puberty" was performed using journal articles on PubMed, Google Scholar, CDC website, UpToDate, and DynaMed.
Results: Literature searches mentioned several possible contributors to early pubertal development. Onset of puberty occurs 2.5 months earlier in the general population and earlier in African American decent, gene malformation, and childhood obesity. Some case reports link tea tree oil, lavender oil, bisphenol A, and pesticides to hormone disturbances. Treatment approaches may include observation, gonadotropin releasing hormone agonists, and growth factor. Histrelin implants have shown the greatest efficacy in delaying menarche by at least one year and increasing adult height by up to 7cm from predicted height. In the reviewed cases, both sisters successfully received the implant to increase height and delay menstruation. These children may be at a higher risk for polycystic ovary syndrome and breast cancer.
Conclusion: These case reports and the literature review documents three cases of familial precocious puberty in a single family along with a comparison to current data on etiology, diagnosis, treatment, and sequella that illustrates a need for public awareness of this disease.
Familial Precocious Puberty: Case Reports and Literature Review
Indianapolis, IN
Background: Precocious puberty is a relatively rare disease with little documented information on etiology or long-term complications.
Methods: Three cases of familial precocious puberty within a single family are reported. Two sisters inherited a gene malformation from their father who was untreated as a child. A literature review of "precocious puberty" was performed using journal articles on PubMed, Google Scholar, CDC website, UpToDate, and DynaMed.
Results: Literature searches mentioned several possible contributors to early pubertal development. Onset of puberty occurs 2.5 months earlier in the general population and earlier in African American decent, gene malformation, and childhood obesity. Some case reports link tea tree oil, lavender oil, bisphenol A, and pesticides to hormone disturbances. Treatment approaches may include observation, gonadotropin releasing hormone agonists, and growth factor. Histrelin implants have shown the greatest efficacy in delaying menarche by at least one year and increasing adult height by up to 7cm from predicted height. In the reviewed cases, both sisters successfully received the implant to increase height and delay menstruation. These children may be at a higher risk for polycystic ovary syndrome and breast cancer.
Conclusion: These case reports and the literature review documents three cases of familial precocious puberty in a single family along with a comparison to current data on etiology, diagnosis, treatment, and sequella that illustrates a need for public awareness of this disease.