Over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most frequently used analgesics. The misuse of these medications occurs frequently and often without the patient’s realization. Inappropriate use can cause acute NSAID overdoses or contribute to serious adverse effects. Health care providers continue to play an important role in emphasizing the safe use of these medications. This article examines the impacts of NSAID misuse in our society and how health care professionals can help address these issues.