Aminoglycoside antibiotics are first-line treatment for many infectious diseases in the pediatric population and are effective in adults. The traditional dosing interval in children is every 8–12 hours. Studies in adults reported equivalent efficacy and equal or less toxicity with once-daily regimens. Despite many studies in the adult population, this approach has yet to become standard practice in most pediatric hospitals. Reasons for lack of acceptance of this strategy in children include rapid aminoglycoside clearance, unknown duration of postantibiotic effect, safety concerns, and limited clinical and efficacy data.
‘This is the peer reviewed version of the following article: Knoderer CA, Everett JA, Buss WF. Clinical issues surrounding once-daily aminoglycoside dosing in children. Pharmacotherapy 2003;23(1):44-56. DOI: 10.1592/phco.220.127.116.11924, which has been published in final form at http://dx.doi.org/10.1592/phco.18.104.22.168924. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving'.
Knoderer, Chad A.; Everett, Julie A.; and Buss, William F., "Clinical Issues Surrounding Once-Daily Aminoglycoside Dosing in Children" (2003). Scholarship and Professional Work – COPHS. 47.