Journal of Pediatric Infectious Diseases Society
We conducted a randomized, controlled clinical trial to determine whether a difference in catheter-associated blood stream infection (CABSI) incidence existed between children who underwent cardiac surgery and had a central venous catheter impregnated with minocycline and rifampin versus those who had a conventional, nonimpregnated catheter after cardiac surgery. Due to a lower number of infections than expected, the study was terminated early. Among 288 evaluable patients, the rates of CABSI and line-related complications were similar between the 2 groups.
Cox, Elaine G.; Knoderer, Chad A.; Jennings, Aimee; Brown, John W.; Rodefeld, Mark D.; Walker, Scott G.; and Turrentine, Mark W., "A Randomized, Controlled Trial of Catheter-Related Infectious Event Rates Using Antibiotic-Impregnated Catheters Versus Conventional Catheters in Pediatric Cardiovascular Surgery Patients" (2013). Scholarship and Professional Work – COPHS. 58.