Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes, Guillermo Montalban-Bravo, Caleb Class, Irene Ganan-Gomez, Rashmi Kanagal-Shamanna, Koji Sasaki, Guillaume Richard-Carpentier, Kiran Naqvi, Yue Wei, Hui Yang, Kelly A. Soltysiak, Kelly Chien, Carlos Bueso-Ramos, Kim-Anh Do, Hagop Kantarjian, Guillermo Garcia-Manero
Caleb Class

Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy, Irene Ganan-Gomez, Hui Yang, Feiyang Ma, Guillermo Montalban-Bravo, Natthakan Thongon, Valentina Marchica, Guillaume Richard-Carpentier, Kelly Chien, Ganiraju Manyam, Feng Wang, Ana Alfonso, Shuaitong Chen, Caleb Class, Rashmi Kanagal-Shamanna, Justin P. Ingram, Yamini Ogoti, Ashley Rose, Sanam Loghavi, Pamela Lockyer, Benedetta Cambo, Muharrem Muftuoglu, Sarah Schneider, Vera Adema, Michael McLellan, John Garza, Matteo Marchesini, Nicola Giuliani, Matteo Pellegrini, Jing Wang, Jason Walker, Ziyi Li, Koichi Takahashi, Joel D. Leverson, Carlos Bueso-Ramos, Michael Andreeff, Karen Clise-Dwyer, Guillermo =Garcia-Manero, Simona Colla
Scholarship and Professional Work – COPHS

Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cance, Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Heffernan P. Heffernan, Joseph R. Marszalek, Funda Meric-Bernstam
Scholarship and Professional Work – COPHS

Activation of gene expression by detergent-like protein domains, Bradley K. Broyles, Andrew T. Gutierrez, Theodore P. Maris, Daniel A. Coil, Thomas M. Wagner, Xiao Wang, Daisuke Kihara, Caleb Class, Alexandre M. Erkine
Scholarship and Professional Work – COPHS

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma, Virginia Giuliani, Meredith A. Miller, Chiu-Yi Liu, Stella R. Hartono, Caleb Class, Christopher A. Bristow, Erika Suzuki, Lionel A. Sanz, Guang Gao, Jason P. Gay, Ningping Feng, Johnathon L. Rose, Hideo Tomihara, Joseph R. Daniele, Michael D. Peoples, Jennifer P. Bardenhagen, Mary K. Geck Do, Qing E. Chang, Bhavatarini Vangamudi, Christopher Vellano, Haoqiang Ying, Angela K. Deem, Kim-Anh Do, Giannicola Genovese, Timothy P. Heffernan, Jeffrey J. Kovacs, Michael Kim, Jason B. Fleming, Ernesto Guccione, Andrea Viale, Anirban Maitra, M. Emilia Di Francesco, Timothy A. Yap, Philip Jones, Giulio Draetta, Alessandro Carugo, Frederic Chedin, Timothy P. Heffernan
Scholarship and Professional Work – COPHS

Type I Interferon Upregulation and Deregulation of Genes Involved in Monopoiesis in Chronic Myelomonocytic Leukemia, Guillermo Montalban-Bravo, Faezeh Darbaniyan, Rashmi Kanagal-Shamanna, Irene Ganan-Gomez, Caleb Class, Caleb Class, Koji Sasaki, Kiran Naqvi, Yue Wei, Hui Yang, Kelly Soltysiak, Kelly Chien, Carlos Bueso-Ramos, Kim-Anh Do, Hagop Kantarjian, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

Evolutionary Action Score Identifies a Subset of TP53 Mutated Myelodysplastic Syndrome with Favorable Prognosis, Rashmi Kanagal-Shamanna, Guillermo Bravo, Panagiotis Katsonis, Koji Sasaki, Caleb Class, Christopher Benton, Elias Jabbour, Kelly Chien, Rajyalakshmi Luthra, Carlos Bueso-Ramos, Tapan Kadia, Michael Andreeff, Nicholas Short, Naval Daver, Mark Routbort, Joseph Khoury, Keyur Patel, Irene Ganan-Gomez, Yue Wei, Gautam Borthakur, Farhad Ravandi, Kim-Anh Do, Kelly Soltysiak, Olivier Lichtarge, L. Medeiros, Hagop Kantarjian, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

Hypomethylating Agents Do Not Alter Novel Splicing Events in Myeloid Neoplasms, Hussein Abbas, Feng Wang, Yue Wei, Hui Yang, Guillermo Bravo, Rashmi Kanagal-Shamanna, Caleb Class, Faezeh Darbaniyan, Jianhua Zhang, Andy Futreal, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

Highly-Sensitive DNA Hydroxymethylation Analysis in Myelodysplastic Syndromes (MDS), Jia Li, Yue Wei, Minjung Lee, Hui Yang, Caleb Class, Stefan Siwko, Yubin Zhou, Deqiang Sun, Guillermo Garcia-Manero, Yun Huang
Scholarship and Professional Work – COPHS

Outcomes of Acute Myeloid Leukemia with Myelodysplasia Related Changes depend on diagnostic criteria and therapy, Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Caleb Class, Koji Sasaki, Farhad Ravandi, Jorge Cortes, Naval Daver, Koichi Takahashi, Nicholas Short, Courtney DiNardo, Elias Jabbour, Gautam Borthakur, Kiran Naqvi, Ghayas Issa, Marina Konopleva, Joseph Khoury, Mark Routbort, Sherry Pierce, Kim Anh, Carlos Bueso-Ramos, Keyur Patel, Hagop Kantarjian, Guillermo Garcia-Manero, Tapan Kadia
Scholarship and Professional Work – COPHS

Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers, David Peng, B. Rodriguez, Lixia Diao, Pierre Gaudreau, Aparna Padhye, Joshua Ochieng, Caleb Class, Jared Fradette, Laura Gibson, Limo Chen, Jing Wang, Lauren Byers, Don Gibbons
Scholarship and Professional Work – COPHS

Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes, Guillermo Montalban-Bravo, Caleb Class, Irene Ganan-Gomez, Rashmi Kanagal-Shamanna, Koji Sasaki, Guillaume Richard-Carpentier, Kiran Naqvi, Yue Wei, Hui Yang, Kelly A. Soltysiak, Kelly Chien, Carlos Bueso-Ramos, Kim-Anh Do, Hagop Kantarjian, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

Long-Term Follow up of a Randomized Phase 2 Study of Low-Dose Decitabine Versus Low-Dose Azacitidine in Lower-Risk Myelodysplastic Syndromes, Guillermo Montalban-Bravo, Elias Jabbour, Caleb Class, Nicholas Short, Rashmi Kanagal-Shamanna, Tapan Kadia, Gautam Borthakur, Naveen Pemmaraju, Koji Sasaki, Zeev Estrov, Jorge Cortes, Farhad Ravandi, Yesid Alvarado, Rami Komrokji, Mikkael Sekeres, David Steensma, Amy DeZern, Gail Roboz, Hui Yang, Hagop Kantarjian, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

Genomic Context and TP53 Allele Frequency Define Prognostic Subgroups and Response Outcomes in TP53 Mutated Myelodysplastic Syndromes, Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Christopher Benton, Caleb Class, Kelly Chien, Koji Sasaki, Kiran Naqvi, Yesid Alvarado, Tapan Kadia, Farhad Ravandi, Jorge Cortes, Naval Daver, Koichi Takahashi, Courtney DiNardo, Elias Jabbour, Gautam Borthakur, Naveen Pemmaraju, Marina Konopleva, Sherry Pierce, Carlos Bueso-Ramos, Michael Andreeff, Keyur Patel, Hagop Kantarjian, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

Comprehensive DNA 5-Hydroxymethylation Landscapes in Myelodysplastic Syndromes (MDS), Jia Li, Yue Wei, Minjung Lee, Caleb Class, Hui Yang, Deqiang Sun, Guillermo Garcia-Manero, Yun Huang
Scholarship and Professional Work – COPHS

Loss of EZH2 Protein Expression in Myelodysplastic Syndrome Correlates with EZH2 Mutation and Portends a Worse Outcome, Ali Sakhdari, Caleb Class, Guillermo Montalban-Bravo, Koji Sasaki, Carlos Bueso-Ramos, Keyur Patel, Joseph Khoury, Hagop Kantarjian, Guillermo Garcia-Manero, L. Medeiros, Rashmi Kanagal-Shamanna
Scholarship and Professional Work – COPHS

Transcriptomic Analysis Implicates Necroptosis in Disease Progression and Prognosis in Myelodysplastic Syndromes, Guillermo Montalban-Bravo, Caleb Class, Irene Ganan-Gomez, Rashmi Kanagal-Shamanna, Koji Sasaki, Guillaume Richard-Carpentier, Kiran Naqvi, Yue Wei, Hui Yang, Kelly Soltysiak, Kelly Chien, Carlos Bueso-Ramos, Kim-Anh Do, Hagop Kantarjian, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

Evolutionary Action (EA) Score of TP53 Mutations Defines Prognostic Subsets within TP53 Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia, Rashmi Kanagal-Shamanna, Guillermo Montalban-Bravo, Caleb Class, Koji Sasaki, Christopher Benton, Kelly Soltysiak, Elias Jabbour, Tapan Kadia, Carlos Bueso-Ramos, Keyur Patel, Mark Routbort, Irene Ganan-Gomez, Yue Wei, Gautam Borthakur, Farhad Ravandi, Kim-Anh Do, L. Medeiros, Hagop Kantarjian, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

KDM6B Overexpression and TET2 Deficiency Cooperatively Drive Development of Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia-like Phenotype in Mice, Yue Wei, Hong Zheng, Naran Bao, Rashmi Kanagal-Shamanna, Caleb Class, Hui Yang, Guillermo Bravo, Irene Ganan-Gomez, Kelly Soltysiak, Kim-Ann Do, Simona Colla, Carlos Bueso-Ramos, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

Abstract 277: Inhibition of protein arginine methylation alters RNA metabolism and DNA damage response providing a new therapeutic strategy in pancreatic ductal adenocarcinoma, Virginia Giuliani, Alessandro Carugo, Meredith Miller, Lionel Sanz, Chiu-Yi Liu, Christopher Bristow, Erika Suzuki, Caleb Class, Stella Hartono, Guang Gao, Ningping Feng, Bhavatarini Vangamudi, Joseph Marszalek, Jeffrey Kovacs, Maria Di Francesco, Frederic Chedin, Philip Jones, Giulio Draetta, Timothy Heffernan
Scholarship and Professional Work – COPHS

WISP1 is associated to advanced disease, EMT and an inflamed tumor microenvironment in multiple solid tumors., Pierre Gaudreau, Sylvie Clairefond, Caleb Class, Pierre Boulay, Pavel Chrobak, Bertrand Allard, Feryel Azzi, Sandra Pommey, Kim Anh, Fred Saad, Dominique Trudel, Marian Young, John Stagg
Scholarship and Professional Work – COPHS

KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice., Yue Wei, Hong Zheng, Naran Bao, Shan Jiang, Carlos Bueso-Ramos, Joseph Khoury, Caleb Class, Yue Lu, Kevin Lin, Hui Yang, Irene Ganan-Gomez, Daniel Starczynowski, Daniel Starczynowski, Kim Anh, Simona Colla, Guillermo Garcia-Manero
Scholarship and Professional Work – COPHS

CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1/PD-l1 blockade, Limo Chen, Lixia Diao, Yongbin Yang, Xiaohui Yi, B. Rodriguez, Yanli Li, Yanli Li, Pamela Villalobos, Tina Cascone, Xi Liu, Lin Tan, Philip Lorenzi, Anfei Huang, Qiang Zhao, Di Peng, Jared Fradette, David Peng, Christin Ungewiss, Jonathon Roybal, Pan Tong, Junna Oba, Ferdinandos Skoulidis, Weiyi Peng, Brett Carter, Youhong Fan, Caleb Class, Jingfen Zhu, Jaime Rodriguez-Canales, Masanori Kawakami, Lauren Byers, Scott Woodman, Vassiliki Papadimitrakopoulou, Ethan Dmitrovsky, Jing Wang, Stephen Ullrich, Ignacio Wistuba, John Heymach, F. Qin, F. Qin, Don Gibbons
Scholarship and Professional Work – COPHS

Overexpression of Histone Demethylase KDM6B in the Hematopoietic Compartment Promotes the Effect of Innate Immune Activation and Results in Myelodysplastic Syndrome (MDS)-like Phenotype in Mice, Yue Wei, Guillermo Garcia-Manero, Hong Zheng, Yu Jia, Naran Bao, Shan Jiang, Joseph Khoury, Caleb Class, Simona Colla, Carlos Bueso-Ramos
Scholarship and Professional Work – COPHS