Date of Award
Spring 5-9-2009
Degree Type
Thesis
Degree Name
Honors Thesis
Department
Chemistry
Abstract
Amide bond formation is an already well documented area of organic chemistry, and is very useful in its application in medicine and pharmaceuticals. However, current methods have not been investigated with regards to optimization of reaction times, solvents, and energy sources. In addition, current methods also utilize toxic solvents to cleave the peptide from the solid phase resin. In our study, we combine the Staudinger and Vilarrasa coupling reactions with microwave irradiation to develop and optimize the synthesis of amide bonds through the use of a solid support. Instead of attaching the peptide to the solid support, our amide bond is left in solution, allowing for easier cleanup and the use of less toxic solvents.
Recommended Citation
Schmidtz, Ryan Patrick, "Solid Phase Amide Synthesis Using Staudinger-Vilarrasa Coupling and Microwave Irradiation" (2009). Undergraduate Honors Thesis Collection. 47.
https://digitalcommons.butler.edu/ugtheses/47