Title

Biodegradable Polymeric Carriers for Delivery of siRNA

Document Type

Book Chapter

Publication Date

2016

Publication Title

Bio-Targets and Drug Delivery Approaches

Abstract

There are several barriers associated with the transport of siRNA to the target. These include catalytic enzymes, defense mechanisms, and other degradation processes. A number of studies showed that the polymeric nonviral vectors can be successfully used to target genes. Compared to the viral vectors, which possess a considerable risk of toxicity, nonviral vectors can be promising for gene delivery and their chemistry, toxicity, stability, and biodegradability can be modified to make them most suitable for gene delivery.

Rights

Version of record can be found through World Cat.