Activation domains of gene-specific transcription factors: are histones among their targets?
Document Type
Article
Publication Date
2004
Publication Title
Biochemistry and Cell Biology
First Page
453
Last Page
459
DOI
http://dx.doi.org/10.1139/o04-036
Abstract
Activation domains of promoter-specific transcription factors are critical entities involved in recruitment of multiple protein complexes to gene promoters. The activation domains often retain functionality when transferred between very diverse eukaryotic phyla, yet the amino acid sequences of activation domains do not bear any specific consensus or secondary structure. Activation domains function in the context of chromatin structure and are critical for chromatin remodeling, which is associated with transcription initiation. The mechanisms of direct and indirect recruitment of chromatin-remodeling and histone-modifying complexes, including mechanisms involving direct interactions between activation domains and histones, are discussed.
Rights
Link leads to full text provided by Canadian Science Publishing.
Recommended Citation
Erkine, Alexander M., "Activation domains of gene-specific transcription factors: are histones among their targets?" (2004). Scholarship and Professional Work – COPHS. 144.
https://digitalcommons.butler.edu/cophs_papers/144