Title

Activation domains of gene-specific transcription factors: are histones among their targets?

Document Type

Article

Publication Date

2004

Publication Title

Biochemistry and Cell Biology

First Page

453

Last Page

459

DOI

http://dx.doi.org/10.1139/o04-036

Abstract

Activation domains of promoter-specific transcription factors are critical entities involved in recruitment of multiple protein complexes to gene promoters. The activation domains often retain functionality when transferred between very diverse eukaryotic phyla, yet the amino acid sequences of activation domains do not bear any specific consensus or secondary structure. Activation domains function in the context of chromatin structure and are critical for chromatin remodeling, which is associated with transcription initiation. The mechanisms of direct and indirect recruitment of chromatin-remodeling and histone-modifying complexes, including mechanisms involving direct interactions between activation domains and histones, are discussed.

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Link leads to full text provided by Canadian Science Publishing.

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