Self-assembling Modified β -cyclodextrin Conjugated siRNA Nanoparticles and Liposomal siRNA Efficiently Knock Down the Mutant Huntingtin Gene in a Modified PC-12 Cell Line

Authors

Rukmini Ladi, Butler University
Sudip Das, Butler UniversityFollow
Nandita Das, Butler UniversityFollow

Document Type

Conference Proceeding

Publication Date

2015

Publication Title

Proceedings of the Annual Meeting of American Association of Pharmaceutical Scientists, Orlando, FL, October 2015

Additional Publication URL

http://abstracts.aaps.org/Published/

Abstract

Purpose: To formulate and characterize liposomal siRNA (LP-siRNA) and cationic β-cyclodextrin siRNA (CD-siRNA) nanoparticle complexes and evaluate their efficacy in knockdown of mutant Huntingtin protein (mHtt) in a modified PC-12 cell line.

Rights

This is an electronic copy of a conference proceeding abstract. The author(s) reserves all rights.

Recommended Citation

Ladi, Rukmini; Das, Sudip; and Das, Nandita, "Self-assembling Modified β -cyclodextrin Conjugated siRNA Nanoparticles and Liposomal siRNA Efficiently Knock Down the Mutant Huntingtin Gene in a Modified PC-12 Cell Line" (2015). Scholarship and Professional Work – COPHS. 234.
https://digitalcommons.butler.edu/cophs_papers/234