Document Type
Article
Publication Date
2009
Publication Title
Pediatric Cardiology
First Page
871
Last Page
872
DOI
http://dx.doi.org/10.1007/s00246-009-9523-1
Abstract
Sildenafil is a phosphodiesterase 5 inhibitor widely used for the treatment of pulmonary hypertension in children. Despite limited available safety and efficacy evidence, use of sildenafil continues to increase. To date, sildenafil use for pediatric pulmonary hypertension has been characterized for 193 children through 16 studies and 28 case series and reports. The primary efficacy data suggest that sildenafil is beneficial for facilitating the weaning of inhaled nitric oxide in children after cardiac surgery. Compiled safety data suggest that sildenafil is well tolerated among children with idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease. This review summarizes the available data describing the use, safety, and efficacy of sildenafil for children with pulmonary hypertension.
Rights
“The final publication is available at Springer via http://dx.doi.org/10.1007/s00246-009-9523-1”.
Recommended Citation
Huddleston, Alice J.; Knoderer, Chad A.; Morris, Jennifer L.; and Ebenroth, Eric S., "Sildenafil for the Treatment of Pulmonary Hypertension in Pediatric Patients" (2009). Scholarship and Professional Work – COPHS. 52.
https://digitalcommons.butler.edu/cophs_papers/52