This study examined the relationship between the APOE ɛ4 allele and postictal confusion in patients with medically intractable temporal lobe epilepsy (TLE). Patients with at least one ɛ4 allele (n = 22) were three times more likely to exhibit postictal confusion (68%) than the 63 patients without ɛ4 (43%). These preliminary results demonstrate that APOE ɛ4 is associated with an increased risk of postictal confusion in patients with medically intractable TLE, suggesting possible dysfunction in neuronal recovery mechanisms.
NOTICE: this is the author’s version of a work that was accepted for publication in Epilepsy Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Epilepsy Research, VOL 81, (2008) DOI# 10.1016/j.eplepsyres.2008.05.003
Chapin, J.S., Busch, R.M., Janigro, D., Doughtery, M., Tilelli, C., Lineweaver, T. T., Naugle, R.I., Diaz-Arrastia, R. & Najm, I. (2008). APOE ε4 is Associated with Postictal Confusion in Patients with Medically Refractory Temporal Lobe Epilepsy. Epilepsy Research, 81, 220-224. doi: 10.1016/j.eplepsyres.2008.05.003 Available from: digitalcommons.butler.edu/facsch_papers/434/