Biochemistry & Molecular Biology
Ester-Protected Ethambutol Derivatives
Document Type
Poster Presentation
Location
Indianapolis, IN
Start Date
13-4-2018 2:30 PM
End Date
13-4-2018 4:00 PM
Sponsor
R. Jeremy Johnson (Butler Univerity)
Description
Ethambutol is a primary antibiotic used to treat tuberculosis (TB), the most deadly infectious disease worldwide. Ethambutol, though, has some serious side-effects including liver damage and inflammation of the optic nerves. Conversion of ethambutol to an ester-protected prodrug could alleviate some of these side-effects and could increase the specificity of the drug for M. tuberculosis. I synthesized 15 ester-protected ethambutol derivatives to determine the toxicity, chemical properties, and biological functions of each derivative. I also analyzed the ability of each ester-protected derivative to act as prodrug. The results of this project provide new insight on how the chemical and biological properties of antibiotics affect their toxicity against TB.
Ester-Protected Ethambutol Derivatives
Indianapolis, IN
Ethambutol is a primary antibiotic used to treat tuberculosis (TB), the most deadly infectious disease worldwide. Ethambutol, though, has some serious side-effects including liver damage and inflammation of the optic nerves. Conversion of ethambutol to an ester-protected prodrug could alleviate some of these side-effects and could increase the specificity of the drug for M. tuberculosis. I synthesized 15 ester-protected ethambutol derivatives to determine the toxicity, chemical properties, and biological functions of each derivative. I also analyzed the ability of each ester-protected derivative to act as prodrug. The results of this project provide new insight on how the chemical and biological properties of antibiotics affect their toxicity against TB.