Chemistry

Wet Chemistry to Purify Metallofullerenes Containing Lutetium Clusters Trapped Inside Higher Fullerene Cages

Document Type

Poster Presentation

Location

Indianapolis, IN

Subject Area

Chemistry

Start Date

13-4-2018 2:30 PM

End Date

13-4-2018 4:00 PM

Description

The encapsulation of rare-earth metals inside the hollow cavity of fullerene cages has led to the prediction of several applications. For example, Gd3N@C80 metallofullerenes have shown preliminary success as candidate MRI contrast agents. Lutetium-based endohedral metallofullerenes have sparked interest as possible X-ray contrast agents and radiopharmaceuticals. Advancing these application areas is being slowed due to a lack of purified samples, which to date are limited to microgram or milligram quantities. In this presentation, we describe a new purification approach that permits the facile enrichment of not only Lu3N@C80, but also other family members, such as Lu3N@C78, Lu3N@C84 and Lu3N@C88. Wet chemistry involves the functionalization of fullerene contaminants with electron-rich amines, whose derivatives are rendered water-soluble upon chemical attack. Further selectivity is attained after a complexation/decomplexation step using a Lewis acid. At this stage, purified samples of lutetium metallofullerenes are readily achieved with HPLC fraction collection.

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Apr 13th, 2:30 PM Apr 13th, 4:00 PM

Wet Chemistry to Purify Metallofullerenes Containing Lutetium Clusters Trapped Inside Higher Fullerene Cages

Indianapolis, IN

The encapsulation of rare-earth metals inside the hollow cavity of fullerene cages has led to the prediction of several applications. For example, Gd3N@C80 metallofullerenes have shown preliminary success as candidate MRI contrast agents. Lutetium-based endohedral metallofullerenes have sparked interest as possible X-ray contrast agents and radiopharmaceuticals. Advancing these application areas is being slowed due to a lack of purified samples, which to date are limited to microgram or milligram quantities. In this presentation, we describe a new purification approach that permits the facile enrichment of not only Lu3N@C80, but also other family members, such as Lu3N@C78, Lu3N@C84 and Lu3N@C88. Wet chemistry involves the functionalization of fullerene contaminants with electron-rich amines, whose derivatives are rendered water-soluble upon chemical attack. Further selectivity is attained after a complexation/decomplexation step using a Lewis acid. At this stage, purified samples of lutetium metallofullerenes are readily achieved with HPLC fraction collection.