Pharmacy, Health Sciences, & Exercise Science
Impact of Rapid MecA Testing in Children with Staphylococcus aureus Bacteremia
Document Type
Oral Presentation
Location
Indianapolis, IN
Start Date
13-4-2018 3:30 PM
End Date
13-4-2018 4:15 PM
Sponsor
Kristen Nichols (Butler University), Chad Knoderer (Butler University)
Description
Rapid molecular technology can detect the mecA resistance gene in Staphylococcus aureus (SA), predicting methicillin susceptibility in under one hour. In combination with antimicrobial stewardship program interventions in adults with SA bacteremia, rapid mecA testing decreases time to targeted therapy. This intervention has not yet been shown effective in pediatric patients or in the absence of real-time stewardship interventions. The objective of this study was to determine if time to optimal therapy decreased following implementation of GeneXpert rapid diagnostic testing (RDT) in a pediatric institution without a formal antimicrobial stewardship protocol for response. The primary outcome was time to optimal therapy, determined by the number of hours from collection of the blood sample to the initiation of an optimal regimen.
Impact of Rapid MecA Testing in Children with Staphylococcus aureus Bacteremia
Indianapolis, IN
Rapid molecular technology can detect the mecA resistance gene in Staphylococcus aureus (SA), predicting methicillin susceptibility in under one hour. In combination with antimicrobial stewardship program interventions in adults with SA bacteremia, rapid mecA testing decreases time to targeted therapy. This intervention has not yet been shown effective in pediatric patients or in the absence of real-time stewardship interventions. The objective of this study was to determine if time to optimal therapy decreased following implementation of GeneXpert rapid diagnostic testing (RDT) in a pediatric institution without a formal antimicrobial stewardship protocol for response. The primary outcome was time to optimal therapy, determined by the number of hours from collection of the blood sample to the initiation of an optimal regimen.