Document Type

Article

Publication Date

2010

Publication Title

Physiology & Behavior

First Page

419

Last Page

423

DOI

http://dx.doi.org/10.1016%2Fj.physbeh.2009.12.007

Abstract

The present experiment examined the influence of excitotoxic lesions of the basolateral amygdala (BLA) on morphine-induced saccharin avoidance. Neurologically intact subjects rapidly learned to avoid drinking the taste conditioned stimulus (CS), an effect that was sustained throughout the experiment. Although the BLA-lesioned (BLAX) rats showed CS avoidance over the first few trials, the effect was not sustained. That is, by the end of the experiment, the BLAX rats were drinking the same amount of saccharin after seven saccharin-morphine trials as they did on the first trial (i.e., prior to the morphine injections). Potential interpretations of the results are discussed including a disruption of the mechanism that governs drug-induced taste avoidance in normal subjects and the more rapid development of tolerance in BLAX rats.

Rights

This is a post-print version of an article originally published in Physiology & Behavior, 2010, Volume 99, Issue 3.

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The version of record is available through: Elsevier.

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