Effect of Apolipoprotein ε4 on Hippocampal and Brain Volume in Intractable Temporal Lobe Epilepsy
Document Type
Article
Publication Date
2011
Publication Title
Epilepsy and Behavior
First Page
88
Last Page
90
DOI
http://dx.doi.org/10.1016/j.yebeh.2011.01.007
Abstract
This study investigated the relationship between the apolipoprotein (APOE) ε4 allele and brain volumes in patients with medically intractable temporal lobe epilepsy (TLE). MRI-based volumetric analyses of the hippocampi, cerebral hemispheres, and whole brain were conducted in 59 patients with TLE (31 with left TLE, 28 with right TLE) with hippocampal sclerosis (HS). There were no differences in hippocampal, hemispheric, or whole brain volumes as a function of ε4 status even after correcting for hemispheric and total brain volumes. However, APOE ε4 carriers showed a trend toward having a smaller discrepancy between ipsilateral and contralateral hippocampal volumes than patients without this allele, and post hoc analyses suggest there may be an increased incidence of bilateral HS in ε4 carriers. In summary, APOE ε4 is not associated with significant hippocampal, hemispheric, or whole brain atrophy in patients with medically intractable TLE. However, ε4 carriers may be more likely to have bilateral HS, with an apparent dose-dependent effect.
Rights
Full Text Made Available By: Elsevier.
Recommended Citation
Busch, R.M., Floden, D., Lineweaver, T.T., Chapin, J.S., Unnwongse, K., Wehner, T., Diaz-Arrastia, R. & Najm, I.M. (2011). Effect of Apolipoprotein ε4 on Hippocampal and Brain Volume in Intractable Temporal Lobe Epilepsy. Epilepsy and Behavior, 21, 88-90. doi: 10.1016/j.yebeh.2011.01.007