Pharmacy, Health Sciences & Exercise Science

A National Survey of Antimicrobial Dosing Strategies at Pediatric Institutions

Document Type

Oral Presentation

Location

Indianapolis, IN

Subject Area

Pharmacy, Health Sciences & Exercise Science

Start Date

11-4-2014 10:15 AM

End Date

11-4-2014 11:45 AM

Description

Background: Ideal antimicrobial utilization includes dosing strategies that serve to optimize pharmacokinetic and pharmacodynamic properties, such as the use of extended-interval dosing of aminoglycosides and extended-infusion dosing of ß-lactam antimicrobials. The adoption of these dosing strategies in pediatric patients has lagged behind the adult population. The prevalence of these dosing strategies in pediatric patients has not been well defined.

Study objective: The objective of this study is to describe the use of extended-interval aminoglycoside dosing and extended and/or continuous infusion dosing of beta-lactam antimicrobials in pediatric hospitals across the country.

Methods: A national survey of children's hospitals was conducted. Practitioners from target hospitals were identified through the Children's Hospital Association, and the survey was sent along with a cover letter e-mail description to identified practitioners. Practitioners received follow-up reminders to complete the survey at weeks 2 and 4, and the survey remained open for 6 weeks. The survey was conducted through SurveyMonkey®, a web-based survey program. Demographic survey questions queried presence of an antimicrobial stewardship program, presence of infectious disease specialists, institution size, and geographic location. Practice based survey questions identified whether institutions are utilizing extended-interval dosing of aminoglycosides, extended and/or continuous infusion dosing of ß-lactam antimicrobials; and reasons cited for not using these dosing strategies. This study is approved by the Butler University Institutional Review Board.

Significance: By assessing the current use of extended-interval aminoglycoside and extended-infusion ß-lactam dosing, this project will raise awareness of the use of these dosing strategiesin pediatric medicine.

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Apr 11th, 10:15 AM Apr 11th, 11:45 AM

A National Survey of Antimicrobial Dosing Strategies at Pediatric Institutions

Indianapolis, IN

Background: Ideal antimicrobial utilization includes dosing strategies that serve to optimize pharmacokinetic and pharmacodynamic properties, such as the use of extended-interval dosing of aminoglycosides and extended-infusion dosing of ß-lactam antimicrobials. The adoption of these dosing strategies in pediatric patients has lagged behind the adult population. The prevalence of these dosing strategies in pediatric patients has not been well defined.

Study objective: The objective of this study is to describe the use of extended-interval aminoglycoside dosing and extended and/or continuous infusion dosing of beta-lactam antimicrobials in pediatric hospitals across the country.

Methods: A national survey of children's hospitals was conducted. Practitioners from target hospitals were identified through the Children's Hospital Association, and the survey was sent along with a cover letter e-mail description to identified practitioners. Practitioners received follow-up reminders to complete the survey at weeks 2 and 4, and the survey remained open for 6 weeks. The survey was conducted through SurveyMonkey®, a web-based survey program. Demographic survey questions queried presence of an antimicrobial stewardship program, presence of infectious disease specialists, institution size, and geographic location. Practice based survey questions identified whether institutions are utilizing extended-interval dosing of aminoglycosides, extended and/or continuous infusion dosing of ß-lactam antimicrobials; and reasons cited for not using these dosing strategies. This study is approved by the Butler University Institutional Review Board.

Significance: By assessing the current use of extended-interval aminoglycoside and extended-infusion ß-lactam dosing, this project will raise awareness of the use of these dosing strategiesin pediatric medicine.