Pharmacy, Health Sciences & Exercise Science

Nafcillin Continuous Infusion Versus Intermittent Infusion Therapy in Pediatric Patients

Presenter Information

Lindsey House, Butler University

Document Type

Oral Presentation

Location

Indianapolis, IN

Subject Area

Pharmacy, Health Sciences & Exercise Science

Start Date

11-4-2014 10:15 AM

End Date

11-4-2014 11:45 AM

Description

Background: Beta-lactam antibacterials exhibit time-dependent killing, meaning that efficacy is associated with the percentage of time that serum drug concentrations exceed the minimum inhibitory concentration (MIC) at the infection site.Nafcillin is an anti-staphylococcal penicillin commonly used in the treatment of infections caused byStaphylococcus aureus.It is traditionally dosed intermittently (every 4 to 6 hours),but continuous infusions allow persistent drug concentrations while decreasing nursing time and IV catheter manipulations. Safety and efficacy of continuous and intermittent infusions of nafcillin have not been compared.Theprimary objective of this study is to compare the efficacy and safety of a continuous nafcillin dosing regimen with that of an intermittent dosing regimen.

Methods: A retrospective cohort study of patients who received nafcillin at Riley Hospital for Children from January 1, 2009 to December 31st, 2012 was completed. Patients at least 30 days old who received more than one dose of nafcillin dosed intermittently (every 4 or 6 hours) or continuously were included. Electronic medical records were reviewed to determine the primary outcome of efficacy. Time to normalization of white blood cell count, immature neutrophil count, body temperature, and inflammatory markers as well as resolution of symptoms specific to the site of infection, as described by the treating physician, were included in the analysis. Presence of adverse drug reactions and factors that may have confounded efficacy or safety outcomes were also collected.

Results:Data analysis is ongoing. Results and conclusion will be presented at the 2014 Butler University Undergraduate Research Conference.

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Apr 11th, 10:15 AM Apr 11th, 11:45 AM

Nafcillin Continuous Infusion Versus Intermittent Infusion Therapy in Pediatric Patients

Indianapolis, IN

Background: Beta-lactam antibacterials exhibit time-dependent killing, meaning that efficacy is associated with the percentage of time that serum drug concentrations exceed the minimum inhibitory concentration (MIC) at the infection site.Nafcillin is an anti-staphylococcal penicillin commonly used in the treatment of infections caused byStaphylococcus aureus.It is traditionally dosed intermittently (every 4 to 6 hours),but continuous infusions allow persistent drug concentrations while decreasing nursing time and IV catheter manipulations. Safety and efficacy of continuous and intermittent infusions of nafcillin have not been compared.Theprimary objective of this study is to compare the efficacy and safety of a continuous nafcillin dosing regimen with that of an intermittent dosing regimen.

Methods: A retrospective cohort study of patients who received nafcillin at Riley Hospital for Children from January 1, 2009 to December 31st, 2012 was completed. Patients at least 30 days old who received more than one dose of nafcillin dosed intermittently (every 4 or 6 hours) or continuously were included. Electronic medical records were reviewed to determine the primary outcome of efficacy. Time to normalization of white blood cell count, immature neutrophil count, body temperature, and inflammatory markers as well as resolution of symptoms specific to the site of infection, as described by the treating physician, were included in the analysis. Presence of adverse drug reactions and factors that may have confounded efficacy or safety outcomes were also collected.

Results:Data analysis is ongoing. Results and conclusion will be presented at the 2014 Butler University Undergraduate Research Conference.