Psychology
The Effects of Local Administration of Flutamide and Fulvestrant in the Right Orbitofrontal Cortex on Impulsive Decision-Making in Male Rats
Document Type
Oral Presentation
Location
Indianapolis, IN
Subject Area
Psychology
Start Date
11-4-2014 2:30 PM
End Date
11-4-2014 4:30 PM
Sponsor
Teresa Aubele-Futch (Wabash College)
Description
Testosterone (T) has been implicated in impulsive decision-making, both in experimental paradigms and in many disorders including ADHD, Pathological Gambling, and mania. However, it is not entirely clear whether T's effects on impulsivity are brought about through the direct effects of testosterone via the androgen receptor (AR) or through estradiol, which can be made from T via aromatization and acts on the estrogen receptor (ER). Further, past studies have suggested that impulsive decision-making is largely moderated by the right orbitofrontal cortex, an area of the brain sensitive to dopamine (DA) and serotonin (5-HT) input. Particularly, previous research has suggested that impulsive decision-making tasks are dependent on the ability for post-synaptic 5-HT1a receptors to alter dopamine release in the OFC. Estradiol has been suggested to moderate 5-HT1a and 5-HT2a receptors, supporting a role for estradiol in moderating impulsive decision-making. In the current study, adult male rats were employed in the rodent Iowa Gambling Task in order to determine the effects of Flutamide, a testosterone antagonist, and Fulvestrant, an estradiol antagonist, in the right orbitofrontal cortex on decision-making impulsivity. Data collection is ongoing.
The Effects of Local Administration of Flutamide and Fulvestrant in the Right Orbitofrontal Cortex on Impulsive Decision-Making in Male Rats
Indianapolis, IN
Testosterone (T) has been implicated in impulsive decision-making, both in experimental paradigms and in many disorders including ADHD, Pathological Gambling, and mania. However, it is not entirely clear whether T's effects on impulsivity are brought about through the direct effects of testosterone via the androgen receptor (AR) or through estradiol, which can be made from T via aromatization and acts on the estrogen receptor (ER). Further, past studies have suggested that impulsive decision-making is largely moderated by the right orbitofrontal cortex, an area of the brain sensitive to dopamine (DA) and serotonin (5-HT) input. Particularly, previous research has suggested that impulsive decision-making tasks are dependent on the ability for post-synaptic 5-HT1a receptors to alter dopamine release in the OFC. Estradiol has been suggested to moderate 5-HT1a and 5-HT2a receptors, supporting a role for estradiol in moderating impulsive decision-making. In the current study, adult male rats were employed in the rodent Iowa Gambling Task in order to determine the effects of Flutamide, a testosterone antagonist, and Fulvestrant, an estradiol antagonist, in the right orbitofrontal cortex on decision-making impulsivity. Data collection is ongoing.