Psychology

Event Title

The Effects of Local Administration of Flutamide and Fulvestrant in the Right Orbitofrontal Cortex on Impulsive Decision-Making in Male Rats

Presenter Information

Andrew Fulton, Wabash College

Document Type

Oral Presentation

Location

Indianapolis, IN

Subject Area

Psychology

Start Date

11-4-2014 2:30 PM

End Date

11-4-2014 4:30 PM

Description

Testosterone (T) has been implicated in impulsive decision-making, both in experimental paradigms and in many disorders including ADHD, Pathological Gambling, and mania. However, it is not entirely clear whether T's effects on impulsivity are brought about through the direct effects of testosterone via the androgen receptor (AR) or through estradiol, which can be made from T via aromatization and acts on the estrogen receptor (ER). Further, past studies have suggested that impulsive decision-making is largely moderated by the right orbitofrontal cortex, an area of the brain sensitive to dopamine (DA) and serotonin (5-HT) input. Particularly, previous research has suggested that impulsive decision-making tasks are dependent on the ability for post-synaptic 5-HT1a receptors to alter dopamine release in the OFC. Estradiol has been suggested to moderate 5-HT1a and 5-HT2a receptors, supporting a role for estradiol in moderating impulsive decision-making. In the current study, adult male rats were employed in the rodent Iowa Gambling Task in order to determine the effects of Flutamide, a testosterone antagonist, and Fulvestrant, an estradiol antagonist, in the right orbitofrontal cortex on decision-making impulsivity. Data collection is ongoing.

This document is currently not available here.

Share

COinS
 
Apr 11th, 2:30 PM Apr 11th, 4:30 PM

The Effects of Local Administration of Flutamide and Fulvestrant in the Right Orbitofrontal Cortex on Impulsive Decision-Making in Male Rats

Indianapolis, IN

Testosterone (T) has been implicated in impulsive decision-making, both in experimental paradigms and in many disorders including ADHD, Pathological Gambling, and mania. However, it is not entirely clear whether T's effects on impulsivity are brought about through the direct effects of testosterone via the androgen receptor (AR) or through estradiol, which can be made from T via aromatization and acts on the estrogen receptor (ER). Further, past studies have suggested that impulsive decision-making is largely moderated by the right orbitofrontal cortex, an area of the brain sensitive to dopamine (DA) and serotonin (5-HT) input. Particularly, previous research has suggested that impulsive decision-making tasks are dependent on the ability for post-synaptic 5-HT1a receptors to alter dopamine release in the OFC. Estradiol has been suggested to moderate 5-HT1a and 5-HT2a receptors, supporting a role for estradiol in moderating impulsive decision-making. In the current study, adult male rats were employed in the rodent Iowa Gambling Task in order to determine the effects of Flutamide, a testosterone antagonist, and Fulvestrant, an estradiol antagonist, in the right orbitofrontal cortex on decision-making impulsivity. Data collection is ongoing.