Pharmacy, Health Sciences, & Exercise Science
Evaluation of the Treatment of Stenotrophomonas maltophilia in Pediatric Patients Requiring Chronic Respiratory Support
Document Type
Oral Presentation
Location
Indianapolis, IN
Start Date
13-4-2018 10:45 AM
End Date
13-4-2018 11:45 AM
Sponsor
Emma Tillman
Description
Stenotrophomonas maltophilia is a multi-drug-resistant Gram-negative rod that colonizes the respiratory tract, yet is typically not pathogenic. Treating a colonization could increase a patient’s risk for a more virulent and/or resistant infection. Chronically ventilated pediatric patients are a population that is at risk for this infection, and there are limited data available to guide treatment. The purpose of this study was to evaluate if treating a positive Stenotrophomonas maltophilia culture improved clinical outcomes in chronically ventilated pediatric patients. Subjects were pediatric patients that were either chronically mechanically ventilated or had a tracheostomy and had a positive culture for Stenotrophomonas maltophilia between August 2014 and March 2017. Patients were excluded if they had a history of cystic fibrosis or a type 1 allergy to sulfamethoxazole-trimethoprim. Patients were divided into two groups, 1) treatment and 2) no treatment. Included were thirty-nine patients with a total of 55 encounters – 25 encounters (22 patients) in the group that was treated and 30 encounters (27 patients) in the group that was not treated. Results to be presented.
Evaluation of the Treatment of Stenotrophomonas maltophilia in Pediatric Patients Requiring Chronic Respiratory Support
Indianapolis, IN
Stenotrophomonas maltophilia is a multi-drug-resistant Gram-negative rod that colonizes the respiratory tract, yet is typically not pathogenic. Treating a colonization could increase a patient’s risk for a more virulent and/or resistant infection. Chronically ventilated pediatric patients are a population that is at risk for this infection, and there are limited data available to guide treatment. The purpose of this study was to evaluate if treating a positive Stenotrophomonas maltophilia culture improved clinical outcomes in chronically ventilated pediatric patients. Subjects were pediatric patients that were either chronically mechanically ventilated or had a tracheostomy and had a positive culture for Stenotrophomonas maltophilia between August 2014 and March 2017. Patients were excluded if they had a history of cystic fibrosis or a type 1 allergy to sulfamethoxazole-trimethoprim. Patients were divided into two groups, 1) treatment and 2) no treatment. Included were thirty-nine patients with a total of 55 encounters – 25 encounters (22 patients) in the group that was treated and 30 encounters (27 patients) in the group that was not treated. Results to be presented.