Pharmacy, Health Sciences, & Exercise Science

Evaluation of the Treatment of Stenotrophomonas maltophilia in Pediatric Patients Requiring Chronic Respiratory Support

Presenter Information

Sarah Firmani, Butler University

Document Type

Oral Presentation

Location

Indianapolis, IN

Start Date

13-4-2018 10:45 AM

End Date

13-4-2018 11:45 AM

Description

Stenotrophomonas maltophilia is a multi-drug-resistant Gram-negative rod that colonizes the respiratory tract, yet is typically not pathogenic. Treating a colonization could increase a patient’s risk for a more virulent and/or resistant infection. Chronically ventilated pediatric patients are a population that is at risk for this infection, and there are limited data available to guide treatment. The purpose of this study was to evaluate if treating a positive Stenotrophomonas maltophilia culture improved clinical outcomes in chronically ventilated pediatric patients. Subjects were pediatric patients that were either chronically mechanically ventilated or had a tracheostomy and had a positive culture for Stenotrophomonas maltophilia between August 2014 and March 2017. Patients were excluded if they had a history of cystic fibrosis or a type 1 allergy to sulfamethoxazole-trimethoprim. Patients were divided into two groups, 1) treatment and 2) no treatment. Included were thirty-nine patients with a total of 55 encounters – 25 encounters (22 patients) in the group that was treated and 30 encounters (27 patients) in the group that was not treated. Results to be presented.

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Apr 13th, 10:45 AM Apr 13th, 11:45 AM

Evaluation of the Treatment of Stenotrophomonas maltophilia in Pediatric Patients Requiring Chronic Respiratory Support

Indianapolis, IN

Stenotrophomonas maltophilia is a multi-drug-resistant Gram-negative rod that colonizes the respiratory tract, yet is typically not pathogenic. Treating a colonization could increase a patient’s risk for a more virulent and/or resistant infection. Chronically ventilated pediatric patients are a population that is at risk for this infection, and there are limited data available to guide treatment. The purpose of this study was to evaluate if treating a positive Stenotrophomonas maltophilia culture improved clinical outcomes in chronically ventilated pediatric patients. Subjects were pediatric patients that were either chronically mechanically ventilated or had a tracheostomy and had a positive culture for Stenotrophomonas maltophilia between August 2014 and March 2017. Patients were excluded if they had a history of cystic fibrosis or a type 1 allergy to sulfamethoxazole-trimethoprim. Patients were divided into two groups, 1) treatment and 2) no treatment. Included were thirty-nine patients with a total of 55 encounters – 25 encounters (22 patients) in the group that was treated and 30 encounters (27 patients) in the group that was not treated. Results to be presented.