Document Type

Article

Publication Date

2009

Publication Title

Epilepsy and Behavior

First Page

145

Last Page

149

DOI

http://dx.doi.org/10.1016/j.yebeh.2009.07.020

Abstract

Objective

The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure.

Methods

In 386 patients, language lateralization and memory lateralization as determined by laterality index (LI) were correlated with each other.

Results

Language lateralization and memory lateralization were positively correlated (r = 0.34, P < 0.01). Correlations differed depending on the presence and type of lesion (χ2 = 7.98, P < 0.05). LIs correlated significantly higher (z = 2.82, P < 0.05) in patients with cortical dysplasia (n = 41, r = 0.61, P < 0.01) compared with the group without lesions (n = 90, r = 0.16, P > 0.05), with patients with hippocampal sclerosis falling between these two groups. Both memory (P < 0.01) and language (P < 0.01) LIs were higher in right- compared with left-sided lesions.

Conclusion

Correlation of language and memory is more pronounced in patients with structural lesions as compared with patients without lesions on MRI.

Rights

NOTICE: this is the author’s version of a work that was accepted for publication in Epilepsy and Behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Epilepsy and Behavior, VOL 16, ISSUE 1, (2009) DOI# 10.1016/j.yebeh.2009.07.020

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